Absolute Positionierung, pixelgenau.

Layer1 {position:absolute; left:10px; top:10px; width:720px; height:80px; background-color: #FFFFFF;}

Layer2
{
position:absolute;
left:10px;
top:100px;
width:150px; background-color: #FFFFFF;
}

Layer3
{position:absolute; left:170px; top:100px; width:400px; height:400px; background-color: #FFFFFF;}

Layer4
{
position:absolute;
left:580px;
top:100px;
width:150px;
background-color: #FFFFFF;
}